The context and aims of the overall research programme and the clinical trial in particular, are described in section 1 – part A. Here, we set out the assumptions we have made for the trial design and conduct, and invite tenderers to respond, suggesting variations where they believe this will help achieve our aims, or will deliver a higher quality or more cost effective survey.

The context and aims of the overall research programme, and the clinical trial in particular, are described in section 1 – part A. Here, we set out the assumptions we have made for the trial design and conduct, and invite tenderers to respond, suggesting variations where they believe this will help achieve our aims, or will deliver a higher quality or more cost effective survey.