Determination of hydrogen cyanide (HCN) bioavailability after food consumption.
Contract Value:
GBP 250K -
Notice Type:
Contract Notice
Published Date:
23 September 2024
Closing Date:
14 October 2024
Location(s):
UK UNITED KINGDOM
Description:
An investigation is sought to determine the bioavailability of hydrogen cyanide in various food items using in vitro gut models and/or in silico methods.
Determination of hydrogen cyanide (HCN) bioavailability after food consumption.. This opportunity has previously been published under ref. 2024/S 000-026248. This notice serves to inform suppliers of an extension to this opportunity.
Tenders are invited to carry out an investigation using an in vitro gut model and/or in silico research methods to determine the bioavailability of hydrogen cyanide in bitter apricot kernels, linseed, almonds, cassava root, marzipan, persipan and tapioca following consumption.
Tenders are invited to carry out an investigation using an in vitro gut model and/or in silico research methods to determine the bioavailability of hydrogen cyanide in bitter apricot kernels, linseed, almonds, cassava root, marzipan, persipan and tapioca following consumption. It is proposed that tenders carry out an investigation in two parts, with preliminary studies used to identify the levels of CNGs, enzymes and HCN in different food types, and a secondary in vitro or in silico model to consider the effects of the gut on HCN bioavailability.