Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment.

The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data.

The multi-modal project aims are:

- Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants.

- Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer.

- Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery.

The requirements include the following:

• To provide a high quality, clinical grade digital pathology service.

• The successful supplier must be of reputable standard with known clinical and academic standing and engagement with the Royal Collage of Pathologists (as this is a national digitisation programme).

• Ideally based within an NHS site to allow for receipt of identifiable information from participants and not require formal MTAs for movement of slides.

• Supplier must demonstrate secure storage for identifiable glass slides.

• Deployment team already established to perform similar process, at scale (expected volumes of 4000 slides per week).

• Clear protocol for handling and anonymisation of participant information and slides.

• Anonymise, scan and digitise 200,000 histopathology slides from solid cancer participants in the 100,000 Genomes Project over one year.

• Digitisation of slides must be performed at x40 magnification on Leica GT450 scanner, in line with previous configurations and analysis.

• Supplier will need to provide scanning of selected slides on a variety of scanners for variability.

• Digital images need to be of DICOM compatible format.

• Supplier will need to have logistics in place to digitise from CellNass directly.

• Transfer these digitised slides to the Genomic England's multi-modal research environment over IBM Aspera.

• Capability to receive and store histopathology slides.

• Capability to conduct quality control protocols and scan all slides.

• Capability to store and transfer image data.