The division of Systems Pharmacology & Pharmacy at LACDR has a focus on translational pharmacology and the development of individualized drug treatment strategies using innovative systems pharmacology approaches. To this end we require instrumentation for the measurement of drugs and drug metabolites and investigational biomarkers in in vitro, in vivo, and patient-derived samples.

The division of Systems Pharmacology & Pharmacy at LACDR has a focus on translational pharmacology and the development of individualized drug treatment strategies using innovative systems pharmacology approaches. To this end we require instrumentation for the measurement of drugs and drug metabolites and investigational biomarkers in in vitro, in vivo, and patient-derived samples.

The 6500+ QTRAP can perform the required functions, which cannot be found in any other commercially available equipment, as follows:

1. Triple quadrupole instruments manufactured by other vendors are all dedicated triple quadrupole mass spectrometers and therefore are functionally limited to traditional triple quadrupole experiments. No other instrument has hybrid ion trap functionality in addition to triple quadrupole functionality and therefore is unable to perform MS3, MRM3, product ion scans at the same LOQs as MRM experiments and Triple-Trap scanning as provided by AB Sciex's state of the art instruments. All of this functionality could be used by the laboratory for research, especially MRM3 and Triple-Trap scanning. Triple-Trap scanning could streamline the development of new assays and will be utilized for simultaneously quantifying drugs/metabolites while acquiring drug/metabolite fingerprint mass spectra that can be matched to database entries.