Determination of hydrogen cyanide (HCN) bioavailability after food consumption.
Contract Value:
GBP 250K -
Notice Type:
Contract Notice
Published Date:
19 August 2024
Closing Date:
19 September 2024
Location(s):
UK UNITED KINGDOM
Description:
Investigation to determine hydrogen cyanide bioavailability in various food types using in vitro gut model and/or in silico research methods.
Determination of hydrogen cyanide (HCN) bioavailability after food consumption.. Tenders are invited to carry out an investigation using an in vitro gut model and/or in silico research methods to determine the bioavailability of hydrogen cyanide in bitter apricot kernels, linseed, almonds, cassava root, marzipan, persipan and tapioca following consumption.
Tenders are invited to carry out an investigation using an in vitro gut model and/or in silico research methods to determine the bioavailability of hydrogen cyanide in bitter apricot kernels, linseed, almonds, cassava root, marzipan, persipan and tapioca following consumption. It is proposed that tenders carry out an investigation in two parts, with preliminary studies used to identify the levels of CNGs, enzymes and HCN in different food types, and a secondary in vitro or in silico model to consider the effects of the gut on HCN bioavailability.