The subject of this publication is the conclusion of non-exclusive agreements on various contrast agent active ingredients / active ingredient combinations within the framework of an open-house procedure, which are prescribed and issued in the SSB at the expense of the health insurance companies in Rhineland-Palatinate and Saarland. More details on the active substances concerned can be found in the division into specialist groups (Appendix 5 to this publication). Contrast media of each future contractual partner can be ordered for a specialty group during the contract period due to the economic efficiency requirement by the contract physicians, who are informed about these economic sources of supply; they are considered economical. Contract physicians are obliged to meet their need for contrast media from a specialist group with the products of the contractual partner or one of the contractual partners. For each specialist group there is a fixed, non-negotiable contract price for the duration of the contract.

Description: Non-ionic iodine-containing monomeric, low-osmolar, water-soluble nephrotropic X-ray contrast media

Application: intrathecal. More possible.

Application areas:

- cervical, thoracic and lumbar myelography and radioculography

- CT myelography

Active ingredients / combinations (ATC): Iohexol (V08AB02) and / or Iopamidol (V08AB04) and / or Iopromide (V08AB05) and / or Iomeprol (V08AB10) and / or Iobitridol (V08AB11) and / or Ioversol (V08AB07) and / or more possible.

Dosage forms: all approved dosage forms of an active ingredient must be offered.

Concentration: 200 mg/ml - 300 mg/ml, all concentrations of an active substance must be offered.

Pack size: all approved pack sizes of an active substance must be offered.

Further information can be found in Appendix 5 to the request for quotation.

Name: ultrasound contrast medium

Application: Intravenous use

Areas of application: echocardiography, others possible

Active ingredients / combinations (ATC): Albumin microspheres, containing perflutren (V08DA01)

Dosage form: all dosage forms of the active ingredient

Concentration: all concentrations possible

Pack size: all pack sizes of the active ingredient

Further information can be found in Appendix 5 to the request for quotation.

Name: ultrasound contrast medium

Application: Intravenous use

Areas of application: echocardiography, Doppler sonography (macro and microvasculature), ultrasound of the lower urinary tract

Active ingredients / combinations (ATC): Sulfur hexafluoride (V08DA05)

Dosage form: all dosage forms of the active ingredient

Concentration: all concentrations possible

Pack size: All pack sizes of the active ingredient.

Further information can be found in Appendix 5 to the request for quotation.

Name: Superparamagnetic MRI contrast agent (iron oxide)

Application: Intravenous use

Indications: MRI of the liver

Active substances/combinations (ATC): Ferucarbotran (V08CB03)

Dosage form: all dosage forms of the active ingredient

Concentration: all concentrations possible

Pack size: All pack sizes of the active ingredient.

Further information can be found in Appendix 5 to the request for quotation.

Name Non-ionic iodine-containing monomeric, low-osmolar, water-soluble nephrotropic X-ray contrast media

Application: intra-arterial and intravenous and intracavity. More possible.

Application areas:

- urography,

- phlebography,

- CT contrast enhancement

- digital subtraction angiography (DSA)

Active ingredients / combinations (ATC): Iohexol (V08AB02) and / or Iopamidol (V08AB04) and / or Iopromide (V08AB05) and / or Iomeprol (V08AB10) and / or Iobitridol (V08AB11) and / or Ioversol (V08AB07) and / or more possible.

Dosage forms: all approved dosage forms of an active ingredient must be offered.

Concentration: 150 mg/ml - 250 mg/ml, all concentrations of an active substance must be offered.

Pack size: all approved pack sizes of an active substance must be offered.

Further information can be found in Appendix 5 to the request for quotation.

Description: Non-ionic iodine-containing dimeric, low-osmolar, water-soluble nephrotropic X-ray contrast media.

Application: intra-arterial and intravenous. More possible.

Application areas:

- cerebral angiography, abdominal angiography, peripheral arteriography, venography,

- urography,

- Contrast enhancement in computed tomography (CT).

Active ingredients / combinations (ATC): Iodixanol (V08AB09) and / or others possible.

Dosage forms: all approved dosage forms of an active ingredient must be offered.

Concentrations must be offered cumulatively:

1. 270 mg/ml (all concentrations of an active substance must be offered)

2. 320 mg/ml (all concentrations of an active substance must be offered)

(at least all areas of application must be covered together).

Pack size: all approved pack sizes of an active substance must be offered.

Further information can be found in Appendix 5 to the request for quotation.

Name: Paramagnetic extracellular linear contrast media for MRI.

Application: Intra-articular application.

Areas of application: Direct magnetic resonance arthrography.

NSF risk: high NSF risk class.

Active ingredients / combinations (ATC): gadopentetic acid (V08CA01).

Dosage forms: All dosage forms of the active ingredient for this indication.

Concentration: 0.002 mmol / ml.

Pack size: All pack sizes of the active ingredient for this indication.

Further information can be found in Appendix 5 to the request for quotation.

Name: Paramagnetic extracellular macrocyclic contrast media for MRI.

Application: Intra-articular application.

Areas of application: Direct magnetic resonance arthrography.

NSF risk: Low NSF risk class.

Active ingredients / combinations (ATC): Gadoteric acid (V08CA02).

Dosage forms: All dosage forms of the active ingredient for this indication.

Concentration: 0.0025 mmol / ml.

Pack size: All pack sizes of the active ingredient for this indication.

Further information can be found in Appendix 5 to the request for quotation.

Name: Paramagnetic extracellular linear contrast media for MRI with renal excretion and partial biliary excretion.

Application: Intravenous. More possible.

Areas of application: MRI of the liver.

NSF risk: Medium NSF risk class.

Active ingredients / combinations (ATC): gadobenic acid (V08CA08).

Dosage forms: All approved dosage forms of an active ingredient.

Concentration: All concentrations possible.

Pack size: All approved pack sizes of the active ingredient.

Further information can be found in Appendix 5 to the request for quotation.

Designation: Paramagnetic combines extracellular and hepatobiliary linear contrast agents for MRI (excretion 50-50).

Application: Intravenous use. More possible.

Areas of application: MRI of the liver.

NSF risk: Medium NSF risk class.

Active ingredients / combinations (ATC): Gadoxetic acid (V08CA10).

Dosage forms: All dosage forms of the active ingredient.

Concentration: All concentrations possible.

Pack size: All pack sizes of the active ingredient.

Further information can be found in Appendix 5 to the request for quotation.

Description: Contrast media containing barium sulphate.

Application: Oral and / or intestinal and / or rectal use.

Areas of application: Representation of parts of the digestive tract and / or the entire digestive tract by CT and / or X-ray, others are possible.

Active ingredients / combinations (ATC): Barium sulfate (V08BA).

Dosage forms: All dosage forms of the active ingredient.

Concentration: All concentrations possible.

Pack size: All pack sizes of the active ingredient.

Further information can be found in Appendix 5 to the request for quotation.

Name: ultrasound contrast medium

Application: Intravenous use

Areas of application: echocardiography, others possible

Active ingredients / combinations (ATC): Phospholipid microspheres, containing perflutren (V08DA04)

Dosage form: all dosage forms of the active ingredient

Concentration: all concentrations possible

Pack size: all pack sizes of the active ingredient

Further information can be found in Appendix 5 to the request for quotation.