Due to an expansion of work activities, Cefas has a requirement for a High-Resolution Mass Spectrometer (HRMS) at its Weymouth laboratory. This will expand upon the existing analytical capabilities and complement the existing triple quadrupole mass spectrometers and HPLC systems on site.

The system is required to have as a minimum three main applications for use, although other applications are expected. These include:

1. High resolution accurate mass MS and MS/MS information for identification and structural elucidation of low molecular weight natural aquatic biotoxins;

2. Untargeted analysis and identification of chemical contaminants (i.e. pharmaceutical compounds) in tissue and environmental samples;

3. Metabolomics workflow.

The system should also incorporate an appropriate chromatographic separation module

https://defra.bravosolution.co.uk/go/52704340017C7AB3607B

Cefas require a MALDI-TOFF benchtop bio-analyser and spectra libraries to rapidly detect bacteria, yeasts, and moulds, with an additional library to detect pathogens that require addition containment or security. The system must have the ability to curate libraries for niche pathogens that are critical for animal, human and environmental health. It would be attractive if these curated libraries could be shared with other collaborative partners (e.g., Animal and Plant Health Agency). These should be able to be shared via Excel or other easily compatible programme.

The instrument must have the option of positive or negative ion mode and features that enable novel future applications, such as AMR (Antimicrobial Resistance), lipid characterisation and new matrices (algae, hymolymph). A cleaning mode for the ion source must be integrated into the device. The technology must allow high mass spectrometric resolution across a wide mass range that is tailored to microorganism identification (bacteria, fungi, yeasts and moulds.

Installation and at least two days training must be provided by the Tenderer and included in the quotation. Pricing for a full-service agreement covering the lifetime of the instrument must also be included (10 years or 50 Million shots of the laser).

https://defra.bravosolution.co.uk/go/79091401017C5A399CA5