The mentioned equipment is intended for the implementation of activities related to the procurement of equipment for the project “Improving Diagnostic Performance by Equipping the Pathology and Medical Genetics Laboratory of the Clinical Emergency County Hospital "Saint Apostle Andrew" Constanța (GePaRD)” – MySMIS code 327722 project co-financed by the European Regional Development Fund through the Health 2021-2027 Program under Policy Objective 4: A more social and inclusive Europe, implemented by the European Pillar of Social Rights; Priority 7: Measures supporting oncology and transplantation fields; Specific objective RSO4.5: Ensuring equal access to medical care and ensuring the resilience of health systems, including in relation to primary health care, as well as promoting the transition from institutional care to family or community care (ERDF). The project's purpose is to significantly improve equitable access to diagnostic medical services and high-quality oncological treatment for all patients in the southeastern region of Romania by equipping the Clinical Emergency County Hospital "Saint Apostle Andrew" Constanța with state-of-the-art medical equipment. The procurement of laboratory equipment is intended to carry out Activity 4 of the Activity Plan: "Procurement, Installation, Configuration, and Testing of Physical Assets" within the aforementioned project. The requested equipment includes molecular and cytogenetic diagnostic medical devices, essential for modernizing the Pathology and Medical Genetics Laboratory of the Clinical Emergency County Hospital “St. Apostle Andrew” Constanța, in order to support personalized cancer treatment: Related operations for providing the system include:

• Complete Cytogenetics and FISH System – allows identification of chromosomal abnormalities and application of the FISH (Fluorescent In Situ Hybridization) technique, being used in the diagnosis of hematological and solid neoplastic diseases. It ensures accuracy and speed in interpreting clinically relevant genetic changes.
• Complete Next Generation Sequencing (NGS) System – provides the ability to analyze multiple mutations from gene panels involved in the onset and evolution of cancer, with direct applications in establishing targeted therapy and patient prognosis.
• Complete Sanger Sequencing System – is used to validate point mutations and complete genetic investigations initiated through NGS, being necessary in cases requiring classical sequential confirmation or individual precision testing.
• Digital PCR System – allows ultra-sensitive detection of nucleic acids, including circulating tumor DNA, from minimally invasive samples (e.g., liquid biopsy), with an important role in disease monitoring and expanding accessibility for patients who cannot undergo surgical intervention.
• RT-PCR (Real-Time PCR) System – intended for identifying viral agents involved in the etiology of certain cancer types (e.g., HPV, EBV, HTLV-1), as well as performing complementary tumor molecular determinations, contributing to elucidating pathogenic mechanisms and defining therapeutic conduct.

Related operations for providing the equipment include:

• Delivery and commissioning of equipment by authorized personnel, operations included in the offered price; in this regard, a compliance declaration will be attached;
• Training of operating and medical staff at the beneficiary's premises, as an integral part of the equipment delivery. The training will include not only the correct and safe use of the equipment but also applying sustainable practices, such as: SEE SPECIFICATIONS SHEET

LOT-0001
Complete Cytogenetics and FISH System.
Complete cytogenetics and FISH system – allows identification of chromosomal abnormalities and applying the FISH technique (Fluorescent In Situ Hybridization), being used in the diagnosis of hematological and solid neoplastic diseases. It ensures accuracy and speed in interpreting clinically relevant genetic changes. Related operations for providing the equipment include:

• Delivery and commissioning of equipment by authorized personnel, operations included in the offered price; a compliance declaration will be attached;
• Training of operating and medical staff at the beneficiary's premises, as an integral part of the equipment delivery. The training will include not only the correct and safe use of the equipment but also applying sustainable practices, such as:
• performing preventive maintenance according to manufacturer recommendations, to prolong the equipment's life and maintain its performance;
• optimizing resource use to reduce energy consumption and minimize waste generated in the work process;
• complying with environmental protection regulations and responsible management of consumables and materials with potential pollutant risk.

LOT-0002
Complete Next Generation Sequencing System.
Complete Next Generation Sequencing (NGS) System – provides the ability to analyze multiple mutations from gene panels involved in the onset and evolution of cancer, with direct applications in establishing targeted therapy and patient prognosis.

LOT-0003
COMPLETE SANGER SEQUENCING SYSTEM.
Complete Sanger Sequencing System – is used to validate point mutations and complete genetic investigations initiated through NGS, being necessary in cases requiring classical sequential confirmation or individual precision testing.

LOT-0004
DIGITAL PCR SYSTEM.
Digital PCR System – allows ultra-sensitive detection of nucleic acids, including circulating tumor DNA, from minimally invasive samples (e.g., liquid biopsy), with an important role in disease monitoring and expanding accessibility for patients who cannot undergo surgical intervention.

LOT-0005
Complete RT-PCR line.
RT-PCR (Real-Time PCR) System – intended for identifying viral agents involved in the etiology of certain cancer types (e.g., HPV, EBV, HTLV-1), as well as performing complementary tumor molecular determinations, contributing to elucidating pathogenic mechanisms and defining therapeutic conduct.