Laboratory reagents and chemical reagents according to the Specifications – 51 lots, for the period October 2025 – April 2026, starting from the date of signing the framework agreement and no later than April 30, 2026.
The number of days until clarification requests can be submitted before the deadline for submitting offers: 15
The contracting authority will respond clearly and completely to all clarification requests 10 days before the deadline for submission of offers.

LOT-0001
Multiplex PCR kit for a 27 loci Y-STR set (AmpFLSTR® Yfiler™Plus - Applied Biosystems or equivalent).
- kit with a set of 27 Y chromosome STR repeat loci + sex marker Amelogenin, amplified in a single reaction, loci recognized in the international identification system CODIS, ENFSI, FSS, and Interpol; validated for use in forensic genetics
100 reactions/kit
Maximum estimated quantity Framework agreement - 3 kits

LOT-0002
Rapid blood pretesting kit (Hexagon OBTI - Human or equivalent).
- Allows rapid detection by immunochromatographic method of human hemoglobin, as a marker for human blood
- the test contains monoclonal antibodies against human hemoglobin
- determines the presence of human hemoglobin by color reaction; the control line has an intensity that correlates with the amount of hemoglobin
- delivered in the form of test cassettes with individual packaging and included procedural quality control and single-use plastic pipettes.
1 box/25 individually packaged test cassettes

Maximum estimated quantity Framework agreement - 10 boxes

LOT-0003
Rapid human semen pretesting kit (Hexagon PSA - Human or equivalent).
- based on rapid, semi-quantitative detection by immunochromatographic method of human prostate-specific antigen (PSA – a prostate glycoprotein) in various fluids or judicial samples;
- the test contains two monoclonal antibodies as active components; based on the reaction of antibodies with human prostate antigen
- determines the presence of human PSA by color reaction; the control line has an intensity that correlates with testing a sample containing PSA at a concentration of 4ng/ml
- delivered in the form of test cassettes with individual packaging and included procedural quality control, with a bottle of 50 ml reaction buffer and single-use plastic pipettes.
1 box/25 individually packaged test cassettes

Maximum estimated quantity Framework agreement - 10 boxes

LOT-0004
Kit for simultaneous detection-quantification of normal human, degraded, and male-origin DNA (PowerQuant® System –Promega or equivalent).
- kit for identifying and quantitatively estimating human DNA and male-origin DNA in a real-time PCR reaction; detection limit between 0.005 - 50ng human DNA/μl
- compatible with 7500 Real-Time PCR System
- generates 5 amplicons: 84 bp (short autosomal), 294bp (degraded autosomal), 81bp (Y chr), 136 bp (Y chr), and internal control of the PCR reaction - 435bp (detects the presence of inhibitors in samples)
- contains human standard DNA, specific primer set for autosomal, degraded, and normal DNA sequences, and specific primers for sequences on the human Y chromosome and reaction mix
- 200 reactions/kit
Maximum estimated quantity Framework agreement - 3 kits

LOT-0005
Hi-Di Formamide.
- used for fragment analysis protocols on the 3500 XL genetic analyzer
bottle of 25 ml
Maximum estimated quantity Framework agreement - 5 bottles

LOT-0006
Tris-Glycine-SDS electrophoresis buffer solution pH 8.3.
- buffer for electrophoresis used for separating proteins through SDS-PAGE;
- BioRad or equivalent, strictly according to the specifications;
- ensure reproducibility of results;
- concentration: 10X;
- composition: 25 mM Tris, 192 mM glycine, 0.1% SDS, pH 8.3;
- must require dilution only with deionized distilled water;
- the product is delivered with a quality and compliance certificate issued by the manufacturer, translated into Romanian;
- the product must be presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, quantity, product lot, expiration date, storage conditions;
- must indicate: for in vitro diagnostics only;
- minimum shelf life of one year from the date of delivery;
packaging: bottle/1 liter.
Maximum estimated quantity Framework agreement - 3 bottles

LOT-0007
Gel for Western Blot electrophoresis.
- polyacrylamide gel, gradient density, used for electrophoretic separation and identification of proteins with molecular weight 10-200 kD;
- must ensure reproducibility of results;
- must be compatible with mini-protean electrophoresis tank, dimensions 8.6 × 6.7 cm, number of wells for loading – 10, amount loaded/well 30 µl;
- must enable chemiluminescent, fluorescent, and colorimetric detection of separated proteins;
- the product is delivered with a quality and compliance certificate issued by the manufacturer, translated into Romanian;
- the product must be presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, quantity, product lot, expiration date, storage conditions;
- must indicate: for in vitro diagnostics only;
- minimum shelf life of one year from the date of delivery;
packaging: package of 10 individually wrapped gels.
Maximum estimated quantity Framework agreement - 3 packages

LOT-0008
Western Blot Transfer Pack.
- used for the rapid transfer of target proteins from gel to membrane;
- compatible with mini-gels and commercial turbo transfer systems;
- each pack must be individually assembled and vacuum sealed, containing two sheets of filter paper, ionic buffer, and a PVDF membrane pre-wetted, with a pore size of 0.2µm;
- dimensions: 10.7 x 8.5 cm;
- the product is presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, quantity, product lot, storage conditions, catalog code;
packaging: package of 10 individually wrapped transfers.
Maximum estimated quantity Framework agreement - 3 packages

LOT-0017
Mayer Type Hematoxylin (compatible with the Bio-Optic processing device).
Mayer Type Hematoxylin
Components: hematoxylin, aluminum and potassium sulfate, potassium iodide, acetic acid, stabilizers.
Must present CE and IVD certificates.
Samples required.
The requested reagents will be accompanied by technical data sheets and have a shelf life of 18-24 months upon delivery.
Maximum estimated quantity Framework agreement - 150 liters

LOT-0018
Eosin Y (compatible with the Bio-Optic processing device).
Eosin Y - alcoholic solution for microscopy. Color: dark red.
Samples required.
The requested reagents will be accompanied by technical data sheets and have a shelf life of 18-24 months upon delivery.
Maximum estimated quantity Framework agreement - 80 liters

LOT-0009
Kit for determining ABO group.
- composed of :
1. ABO FluoGene
- Kit intended for genotyping alleles of the ABO system;
- INNO TRAIN or equivalent, strictly according to the specifications;
- able to distinguish between the most common alleles A, A2, B, O1, and O2;
- PCR plates must contain pre-aliquoted and lyophilized mixes that allow amplification of specific markers;
- each oligo mix must contain primers stable at -20°C for 22 months, internal controls, and fluorescently labeled oligonucleotides, as follows: fluorochrome 1 – ABO specific probes, fluorochrome 2 – A HGH control and fluorochrome 3 – ABO specific probes in case of multiplex reaction;
- number of tubes with fluomix: 10;
- number of thermal sheets: 10;
- reaction tubes with fluomix must contain dNTPs, PCR buffer, and Taq Polymerase: one tube/type;
- technical compatibility with the FluoVista system and with Ready DNA isolation spin kit;
- the kits will be delivered along with interpretation software;
- authorization from the manufacturer for the delivery of the products, ISO certificate, CE of the manufacturer, quality/lot certificate, importer ISO certificate;
- the distributor is required to ensure delivery of the kits within 72 hours of their packaging, in dry ice, to ensure the specific conditions specified by the manufacturer, with no melting allowed during transport; documents proving the time period from packaging to delivery must be presented;
- minimum shelf life of one year from the date of delivery;
- original prospect in English and translation in Romanian, storage conditions -20 °C, indicating for in vitro diagnostics only;
- 10 typings/box (96 PCR reactions/typing);
- 2 boxes/kit;

2. Ready DNA isolation spin kit
- kit for DNA isolation from different types of tissues, biological products, and blood;
- INNO TRAIN or equivalent, strictly according to the specifications;
- unique protocol for different types of samples;
- binding capacity: 20 µg;
- operation mode: by centrifugation;
- elution solution: TRIS HCl Buffer – pH 8.5-9
- elution volume: 100-200µl;
- sample volume: blood – up to 200 µl; cell cultures - max. 106 cells; tissues - max 15 mg;
- the kit includes:
 Buffer1 (guanidine HCl) – 40 ml,
 Buffer2 -50 ml,
 BufferX – 44 ml,
 Tris –Buffer – 88 ml,
 Powder protease – 4.04 ml,
 RNase A powder – 2.2 ml,
 Spin Mini Columns – 200 pcs.,
 2 ml tubes – 200 pcs.,
- storage at room temperature;
- stability 12 months;
- technical compatibility with HLA FluoGene kits;
- the product must be presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, product lot, expiration date, storage conditions, for in vitro diagnostics only;
- minimum shelf life of one year from the date of delivery;
- original prospect in English and translation in Romanian;
- 50 isolations/box;
1 box/kit.

Maximum estimated quantity Framework agreement - 3 kits

LOT-0025
CK-MB (ERBA Lachema – XL 200 or equivalent).
Ready-to-use reagent, without intermediate preparation steps, for the quantitative determination, in vitro, of creatine kinase MB in serum, plasma samples;
The reagent must be compatible with the XL 200 analyzer;
Method principle: immunoinhibition;
Reagent kit packaging:
R 1 2 x 44 ml
R2 2 x 11 ml
Validity: 12 months from the purchase date.

Maximum estimated quantity Framework agreement - 5 kits

LOT-0026
CALIBRATOR BIOCHEMISTRY (BioSystems or equivalent).
Lyophilized calibrator based on human serum;
The concentrations of the calibrator are suitable for calibrating analytes determined on automatic analyzers;.
Reagent kit packaging:
R1 5 x 5 ml
Validity: 12 months from the purchase date.

Maximum estimated quantity Framework agreement - 3 kits

LOT-0010
ELISA Kit Cardiac Troponin I.
- kit for quantitative determination of human cTnI in serum and plasma by enzyme immunoassay analysis technique, Monobind or equivalent, strictly according to the specifications;
- to utilize the competitive inhibition technique, colorimetric method;
- sensitivity: 0.063 - 0.075 ng/ml;
- detection range: 0 – 20 ng/ml;
- must contain:
 a ready-to-use microplate, with 12 strips of 8 wells covered with anti-human cTnI antibodies;
 lyophilized standard – 6 tubes x 1 ml with the following concentrations: 0, 0.4, 1.25, 2.5, 7.5, 20 ng/ml;
 stabilized cTnI enzyme - mouse monoclonal IgG antibodies labeled enzymatically – 1 tube x 13 ml;
 concentrated washing solution – 1 tube x 20 ml;
 substrate solution A - TMB – 1 tube x 7 ml;
 substrate solution B - peroxidase – 1 tube x 7 ml;
 stop reaction solution - HCL 1N – 1 tube x 8 ml;
- the reaction should be read at 450 nm with reference to 620 nm;
- must indicate for in vitro diagnostics;
- must not interfere with hemolyzed, icteric, or lipemic samples in the following concentrations: hemoglobin under 4.0 mg/ml, lipemia under 25 mg/ml, and bilirubin under 2.5 mg/ml;
- the product is delivered with a quality and compliance certificate issued by the manufacturer, translated into Romanian;
- the product must be presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, quantity, product lot, expiration date, storage conditions;
- must indicate: for in vitro diagnostics only;
- minimum shelf life of one year from the date of delivery;
packaging: kit.

Maximum estimated quantity Framework agreement - 4 kits

LOT-0011
Absolute Ethanol.
- reagent for molecular biology, Sigma-Aldrich, Merck, Fluka or equivalent, strictly according to the specifications;
- purity ≥99.9%
- molecular weight; 74.12 g/mol
- presentation form: colorless liquid;
- density: 0.71 g/cm3 at 20 °C;
- solubility in water: 65 g/l at 20 °C;
- total impurities: water ≤0.03%, peroxides (such as H2O2) ≤1 ppm;
- UV absorption:
 λ: 218 nm Amax: 1.0
 λ: 250 nm Amax: 0.20
 λ: 275 nm Amax: 0.04
 λ: 300-400 nm Amax: 0.01
- quality and compliance certificate issued by the manufacturer and translated into Romanian
- the product must be presented in the manufacturer's original packaging, specifying: manufacturer name, product denomination, quantity, product lot, expiration date, storage conditions, added preservatives;
- minimum shelf life of one year from the date of delivery;
packaging: glass or plastic container/1 liter.

Maximum estimated quantity Framework agreement - 5 liters

LOT-0012
Methanol.
- chemical reagent for analysis, Sigma-Aldrich, Merck, Fluka or equivalent, strictly in accordance with the specifications;
- purity: over 99.6%
- molecular weight: 32.04
- total impurities:
- ≤0.01% bases (as NH3)
- ≤0.03% acids (as HCOOH)
- ≤0.1% water
- refractive index: n20/D 1.329
- density: 0.791 g/mL at 25 °C
- residue after evaporation: ≤0.01%;
- storage at room temperature;
- quality and compliance certificate issued by the manufacturer translated into Romanian
- the product must be presented in the original packaging of the manufacturer, which must specify: the name of the manufacturer, the designation, the quantity, and the lot of the product, the expiration date, storage conditions, added preservatives;
- minimum shelf life of one year from the date of delivery;
- must indicate: p.a;
- packaging: glass or plastic container/1 liter

Estimated maximum quantity Framework agreement - 5 liters

LOT-0013
Test kit for A1, B, and O red blood cells.
Kit for determining specific agglutinins of the ABO blood system;
contains:
- a 10 ml bottle with 4% A1 group red cells, Rh(D) positive - phenotype CcDEe, washed and stored in modified Alsever's solution containing 0.01% neomycin sulfate, 0.033% chloramphenicol, and 5 ppm amphotericin B;
- a 10 ml bottle with 4% B group red cells, Rh(D) negative - phenotype ccddee, washed and stored in modified Alsever's solution containing 0.01% neomycin sulfate, 0.033% chloramphenicol, and 5 ppm amphotericin B;
- a 10 ml bottle with 4% O group red cells, Rh(D) positive – phenotype CcDEe, washed and stored in modified Alsever's solution containing 0.01% neomycin sulfate, 0.033% chloramphenicol, and 5 ppm amphotericin B;
- packaging: 10 ml bottles with calibrated dropper;
- the products must be presented in the original packaging of the manufacturer, which must specify: the name of the manufacturer, the designation, the quantity per bottle, the lot of the product, the expiration date, storage conditions 2-8 °C; only for in vitro diagnosis;
- the products must be tested and negative for HIV, HCV, HBsAg, and syphilis.
- shelf life: minimum 1 month from the date of delivery;
- packaging: kit containing 3 bottles of 10 ml each (one bottle with A1 group red cell suspension, one bottle with B group red cell suspension, and one bottle with O group red cell suspension) with calibrated dropper.
- 12 kits are required annually with monthly delivery – 1 kit/month based on a delivery schedule.

Estimated maximum quantity Framework agreement - 12 kits

LOT-0014
Rapid human sperm pre-test kit.
- kit based on rapid, semi-quantitative detection, by immunochromatographic method, of human prostatic antigen (PSA – prostatic glycoprotein) in various fluids or judicial samples;
- the test contains two monoclonal antibodies as active components;
- based on the reaction of antibodies with human prostatic antigen;
- determines the presence of human PSA by color reaction; the control line has an intensity that correlates with testing a sample containing PSA in a concentration of 4 ng/ml
- delivered in the form of test cassettes with individual packaging, procedure quality control included, and disposable plastic pipettes.
- the products must be presented in the original packaging of the manufacturer, which must specify: the name of the manufacturer, the designation, the quantity, and the lot of the product, the expiration date, storage conditions, added preservatives;
- minimum shelf life of one year from the date of delivery;
packaging: kit with 25 individually packed test cassettes.

Estimated maximum quantity Framework agreement - 20 kits

LOT-0015
Ethyl alcohol 96% (compatible with Bio-Optica processing equipment).
histological reagent used in tissue processing and standard histological stains
- (non-food use) Grade 96% Technical specifications according to stas 113;
- clear colorless appearance, molecular mass 46.07 g/mol
Packaging: plastic bottle/1 liter
Samples requested
The requested reagents will be accompanied by technical data sheets and will have a shelf life, at the time of delivery, of 18-24 months.

Estimated maximum quantity Framework agreement - 400 liters

LOT-0016
Toluene (compatible with Bio-Optica processing equipment).
Solvent used for clarifying slides with histopathological preparations
Chemical formula C7H8
M=92.14 g/mol
Vapor pressure: 22 mmHg (20°C)
Assay:≥99.7%
Al:≤0.5 ppm
Ba:≤0.1 ppm
Bi:≤0.1 ppm
Packaging glass bottle: 2.5 l
Samples requested
The requested reagents will be accompanied by technical data sheets and will have a shelf life, at the time of delivery, of 18-24 months.

Estimated maximum quantity Framework agreement - 300 liters

LOT-0019
Perls Van Gieson kit (Bio Optica or equivalent).
Perls Van Gieson kit, original product from Bio-Optica, Italy
Kit for determining iron in connective tissue.
Components
A) Potassium ferrocyanide solution 30 ml
B) Acid activation solution 30 ml
C) Van Gieson Picrofuchsin 30 ml
Results:
Ferric iron reagent: blue
Collagen: Violet - Red
Cytoplasm, muscle, cornified epidermis, neuroglia, and erythrocytes - Light yellow
Storage temperature 15-25 °C.
Procedure time 35 minutes
Stability: After first opening, the product can be used until the expiration date if correctly stored.
Validity 2 years
CE marked product.
Samples requested
The requested reagents will be accompanied by technical data sheets and will have a shelf life, at the time of delivery, of 18-24 months.

Estimated maximum quantity Framework agreement - 3 kits

LOT-0020
Van Gieson kit (Bio Optica or equivalent).
Van Gieson
-recommended method for differentiating collagen fibers in connective tissue
Nuclei: black
Collagen fibers: purple / violet red
Cytoplasm, smooth and striated muscle, cornified epithelium, neuroglia, and erythrocytes: yellow
Composition:
Weigert iron hematoxylin solution B 1000 ml
Weigert iron hematoxylin solution A 1000 ml
Van Gieson Picrofuchsin 2 x 500 ml
Storage temperature: 15-20° C.
Working time 35 minutes.
Stability: After first opening, the product can be used until the expiration date if correctly stored.
Validity 2 years
Samples requested
The requested reagents will be accompanied by technical data sheets and will have a shelf life, at the time of delivery, of 18-24 months.

Estimated maximum quantity Framework agreement - 12 kits

LOT-0021
Hydrogen peroxide.
Solution used in the immunohistochemical process
Chemical formula: H2O2
M=34.01 g/mol
Content: minimum 30%
Density: 1.11 g/ml
Chlorides: max 0.001 %
Iron: max. 0.0005 %
Heavy metals: max. 0.0005 %
Sulfates: max. 0.001%
Org. acidity (H2SO4): max. 0.05 %
Residue on evaporation: max 0.01 %
Packaging bottle: 1 l
Samples requested
The requested reagents will be accompanied by technical data sheets and will have a shelf life, at the time of delivery, of 18-24 months.

Estimated maximum quantity Framework agreement - 8 liters

LOT-0022
XL MULTICAL (MULTIPARAMETRIC CALIBRATOR) (ERBA Lachema – XL 200 or equivalent).
Lyophilized calibrator based on human serum;
The concentrations of the calibrator are suitable for calibrating the analytes determined on automatic analyzers;.
Packaging reagent kit:
R1 4 x 3 ml
Validity: 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 5 kits

LOT-0023
NORMAL CONTROL (ERBA Lachema – XL 200 or equivalent).
Lyophilized human control serum intended for monitoring accuracy and precision of commonly used biochemical tests, within normal limits;
Packaging reagent kit:
R1 4 x 5 ml
R2 1 x 20 ml
Validity 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 5 kits

LOT-0024
PATHOLOGICAL CONTROL (ERBA Lachema – XL 200 or equivalent).
Lyophilized human control serum intended for monitoring accuracy and precision of commonly used biochemical tests, within pathological limits;
Packaging reagent kit:
R1 4 x 5 ml
R2 1 x 20 ml
Validity 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 5 kits

LOT-0027
NORMAL BIOCHEMICAL CONTROL SERUM – (LEVEL I) (BioSystems or equivalent).
Lyophilized human control serum intended for monitoring accuracy and precision of commonly used biochemical tests, within normal limits;
Packaging reagent kit:
R1 5 x 5 ml
Validity 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 3 kits

LOT-0028
PATHOLOGICAL BIOCHEMICAL CONTROL SERUM - (LEVEL II) (BioSystems or equivalent).
Lyophilized human control serum intended for monitoring accuracy and precision of commonly used biochemical tests, within pathological limits;
Packaging reagent kit:
R1 5 x 5 ml
Validity 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 3 kits

LOT-0029
TROPONIN I + CK-MB + MYOGLOBIN.
Rapid test for the qualitative determination, in vitro, of cardiac troponin I and myoglobin in serum, plasma, or whole blood;
Method: immunochromatographic;
Reagent kit packaging: 25 tests
Each test cassette is individually packaged in the manufacturer's original packaging, which must specify: the name of the manufacturer, the designation, the quantity, and the lot of the product, the expiration date, storage conditions, added preservatives, with the mention only for in vitro diagnosis;
Each kit is accompanied by the original prospectus and translation into Romanian;
Validity: 2 years from the date of purchase.

Estimated maximum quantity Framework agreement - 60 kits

LOT-0030
XL Wash (ERBA Lachema – XL 200 or equivalent).
Concentrated cleaning solution. Contains a surfactant that solubilizes proteins and cleans microcuvettes;
Reagent kit packaging: 4 x 100 ml;
Stability: 15 - 25ºC until the expiration date;
Validity: 12 months from the date of purchase.

Estimated maximum quantity Framework agreement - 3 kits

LOT-0031
Ethyl acetate.
Chemical reagent used for GC-MS (gas chromatography)
- Merck, Sigma quality, or equivalent
-specification of compatibility of composition and purity for GC-MS analysis
-water-max 0.02%, nonvolatile <0.0005%, bases (NH3) max 0.0005%
- GC/ECD (retention range 1,2,4-trichlorobenzene to decachlorobiphenyl individual signals (lindane standard)) – max 3pg/ml
-quality and compliance certificate issued by the manufacturer translated into Romanian
-the products must be presented in the original packaging of the manufacturer, which must specify: name of the manufacturer, designation, quantity, and lot of the product, expiration date, storage conditions, added preservatives,
-delivery of products with at least 18 months before the expiration date;
-packaging: 1 liter each glass bottle

Estimated maximum quantity Framework agreement - 25 liters

LOT-0032
Acetonitrile hypergrade pure LC-MS.
Chemical reagent used for LC-MS, min 99.9%
-specification of compatibility of composition and purity for LC-MS analysis
- vapor pressure 128 hPa (20℃)
- water ≤0.01%, acidity ≤0.0002 meq/g, alkalinity ≤0.0002 meq/g, aluminum ≤10 ppb, calcium ≤10 ppb, iron ≤10 ppb
-quality and compliance certificate issued by the manufacturer translated into Romanian
-products must be presented in the original packaging of the manufacturer, which must specify: name of the manufacturer, designation, quantity, and lot of the product, expiration date, storage conditions, added preservatives
-delivery of products with at least 18 months before the expiration date,
-packaging 1 liter each glass bottle

Estimated maximum quantity Framework agreement - 10 liters

LOT-0033
Glacial acetic acid.
Chemical reagent for analysis
-min purity 99.8%
-nonvolatile <0.005%, aluminum <0.00005%, sulfate <0.0005%, chlorine <0.0002%, reducing agents of KMnO4 <0.01%
- Merck, Sigma quality, or equivalent
-quality and compliance certificate issued by the manufacturer translated into Romanian
-products must be presented in the original packaging of the manufacturer, which must specify: name of the manufacturer, designation, quantity, and lot of the product, expiration date, storage conditions, added preservatives
-delivery of products with at least 18 months before the expiration date;
-packaging 1 liter each bottle

Estimated maximum quantity Framework agreement - 4 liters

LOT-0034
Conc. hydrochloric acid.
Chemical reagent for analysis
Min 37%, max residue 0.0005%, nonvolatile max 0.005%, ammonium max 0.0001%, chlorine max 0.00005%, aluminum max 0.000005%, calcium max 0.00005%, color ≤10 hazen
- Merck, Sigma quality, or equivalent
-quality and compliance certificate issued by the manufacturer translated into Romanian
-products must be presented in the original packaging of the manufacturer, which must specify: name of the manufacturer, designation, quantity, and lot of the product, expiration date, storage conditions, added preservatives
-delivery of products with at least 18 months before the expiration date;
-packaging 1 liter each bottle

Estimated maximum quantity Framework agreement - 10 liters

LOT-0035
0.1 N hydrochloric acid.
Chemical reagent for analysis
-c(HCl)=0.1 mol/l +/- 0.1%, Merck, Sigma quality, or equivalent
-quality and compliance certificate issued by the manufacturer translated into Romanian
-products must be presented in the original packaging of the manufacturer, which must specify: name of the manufacturer, designation, quantity, and lot of the product, expiration date, storage conditions, added preservatives
-delivery of products with at least 18 months before the expiration date;
- packaging 1 liter each bottle

Estimated maximum quantity Framework agreement - 5 liters

LOT-0036
Isopropyl alcohol (isopropanol).
Chemical reagent used for HPLC
- purity ≥ 99.8%, acidity ≤ 0.0001 meq/g, alkalinity ≤ 0.0001 meq/g
Reducers 0.0002%, residue on evaporation 0.0001%, water ≤ 0.05%

- compatibility specification of composition and purity for HPLC analysis;
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date
- packaging: 1 liter each glass bottle;

Maximum estimated quantity Framework agreement - 15 liters

LOT-0037
Methyl alcohol - toxicology.
Chemical reagent used for HPLC/GC/MS: min 99.9%
- quality Merck, Sigma or equivalent
- compatibility specification of composition and purity for GC/MS and HPLC analysis
- water < 0.1%;
- quality and compliance certificate issued by the manufacturer translated into Romanian;
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date;
- packaging: glass bottle/2.5 liters or 1l/glass bottle

Maximum estimated quantity Framework agreement - 20 liters

LOT-0038
Hypergrade methyl alcohol purity LC-MS.
Chemical reagent used for LC-MS, min 99.9%
- compatibility specification of composition and purity for LC-MS analysis
- vapor pressure 128 hPa (20℃)
- water ≤ 0.01%, acidity ≤ 0.0002 meq/g, alkalinity ≤ 0.0002 meq/g, aluminium ≤ 10 ppb, calcium ≤ 10 ppb, iron ≤ 10 ppb
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product,
expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date,
- packaging: 1 liter each glass bottle

Maximum estimated quantity Framework agreement - 20 liters

LOT-0039
Ammonium 25%.
Chemical reagent for analysis solution 25%
boiling point 37.7 °C (1013 hPa), density 0.903 g/cm3 (20 °C), non-volatile ≤ 10 ppm, carbonate ≤ 10 ppm, chloride ≤ 0.5 ppm, phosphate ≤ 0.5 ppm, sulfate ≤ 2 ppm, reducers ≤ 5 ppm
- quality Merck, Sigma or equivalent
- quality and compliance certificate issued by the manufacturer translated into Romanian;
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives;
- delivery of products at least 18 months before the expiration date,
- packaging: bottle /1 liter

Maximum estimated quantity Framework agreement - 3 liters

LOT-0040
LC-MS grade water.
Deionized water for LC-MS
- compatibility specification of composition and purity for LC-MS analysis
- ionization index n20/D 1.34, vapor pressure 23 hPa (20℃)
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives,
- delivery of products at least 18 months before the expiration date;
Packaging: glass bottle of 2.5l

Maximum estimated quantity Framework agreement - 15 bottles

LOT-0041
Dichloromethane.
Analytical purity chemical reagent used for GC/GC-MS: min 99.9%
- water max 0.01%, non-volatile max 0.001%, acidity (HCl) max 0.001%, residue on evaporation max 0.001%
- compatibility specification of composition and purity for GC-MS analysis
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product,
expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date,
- packaging: 1 liter or 2.5l each glass bottle

Maximum estimated quantity Framework agreement - 35 liters

LOT-0042
Ethyl ether.
Chemical reagent for analysis;
- purity ≥ 99 %;
- molecular weight; 74.12 g/mol - presentation form: colorless liquid;- density: 0.71 g/cm3 at 20 °C;- non-volatile max 0.7%, acidity max 0.0002%
water ≤ 0.03%
peroxides (such as H2O2) ≤ 1 ppm
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity, and lot number of the product, expiration date, storage conditions, added preservatives,
- packaging: glass container /1 liter

Maximum estimated quantity Framework agreement - 25 liters

LOT-0043
Sodium hydroxide.
Chemical reagent for analysis
- purity min 99%
- carbonates max 1.5%, chloride max 0.002%, sulfates max 0.0008%, nitrogen max 0.0005%
- packaging 1Kg each bottle
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date

Maximum estimated quantity Framework agreement - 3 kg

LOT-0044
Isooctane.
Chemical reagent for analysis
- purity ≥ 99.5%, color < 10 hazen, water ≤ 0.01%, residue on evaporation ≤ 0.001%,
Acidity 0.003%
- compatibility specification of composition and purity for GC-MS analysis
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product,
expiration date, storage conditions, added preservatives
- delivery of products at least 18 months before the expiration date,
- packaging: 1 liter / glass bottle

Maximum estimated quantity Framework agreement - 3 liters

LOT-0045
Negative control serum.
- Liofilized serum produced based on human matrix
- negative control serum tested for therapeutic drugs and illicit compounds
- control serum for use as a negative control and for diluting concentrated samples from patients
- stability min 5 days at 2-8ºC after reconstitution; reconstitution is done in distilled water
- shelf life min. 2 years in lyophilized state
- delivery with min. 24 months before the expiration date
- compliance certificate issued by the manufacturer
- packaging= 10 bottles x 2.5 ml reconstituted solution (one package)

Maximum estimated quantity Framework agreement - 6 packages

LOT-0046
Ammonium sulfate.
Chemical reagent purity for GC
- purity ≥ 99.5%, insoluble residue ≤ 0.001%
- chlorides (Cl) - max. 0.0005%; - nitrates - max. 0.001%; - copper - max. 0.001%; Fe ≤ 0.0002%;
- potassium max. 0.01%; FeII - max. 0.001%; Mg max. 0.001%; Mn - max. 0.005%; Pb - max. 0.0005%; Zn max. 0.001%; phosphates ≤ 0.0005%; heavy metals ≤ 0.0005%
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions, added preservatives, - packaging
- bottle of 500g or 1kg
- delivery of products at least 18 months before the expiration date

Maximum estimated quantity Framework agreement - 25 kg

LOT-0047
Sodium sulfate.
Chemical reagent for analysis purity min. 99%
- Chlorides (Cl) %-max. 0.003
- Total nitrogen % max. 0.002
- phosphates % max. 0.003
- iron % max. 0.001
- Pb % max. 0.002
- pH solution 5% = 5-8
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product,
expiration date, storage conditions, added preservatives,
- delivery of products at least 18 months before the expiration date
- packaging= plastic bottle 500g or 1 kg

Maximum estimated quantity Framework agreement - 25 kg

LOT-0048
Rapid immunological test for ketamine in urine.
- for urine quantities under 1ml
- individually packaged cassette type tests, with individual pipette
- cut-off limit - cut-off parameter KET 500 ng/ml
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions;
- delivery of products at least 18 months before the expiration date;
- packaging individual test min 20 pcs x 1 box

Maximum estimated quantity Framework agreement - 2000 pieces

LOT-0049
Immunological test for drugs in urine Evidence MultiSTAT.
-compatible with Evidence MultiSTAT
- for the detection of drugs in urine
- quality and compliance certificate issued by the manufacturer translated into Romanian
- products must be presented in the original packaging of the manufacturer, which must specify: manufacturer name, designation, quantity and lot number of the product, expiration date, storage conditions;
- delivery of products at least 18 months before the expiration date;
- packaging: kit for 12 determinations

Maximum estimated quantity Framework agreement - 10 kits

LOT-0050
Drug analysis kit in blood for LCMSMS.
The analytical kit must be specifically designed for the analysis of abuse drugs by mass spectrometry coupled with liquid chromatography.

The kit must be validated for in vitro diagnosis (IVD) for screening of abuse drugs but also for their quantitative confirmation.
The kit must be validated for quantitative determination of abuse drugs for clinical use and in forensic medicine.
The kit must be suitable for the determination of the following abuse drugs: 6-MAM, 11-OH-THC, amphetamine, BEG, buprenorphine, cocaethylene, cocaine, codeine, 9-THC, 9-THC-COOH, methyl ecgonine ester, EDDP, fentanyl, ketamine, MBDB, MDA, MDE, MDMA, methadone, methamphetamine, morphine, norbuprenorphine.
The kit must allow the analysis of 22 abuse drugs and metabolites.
The kit must contain mobile phase (M1 and M2) in a volume of 2 x 500 mL for each (M1 and M2)
The kit must contain deproteinization solution for blood sample (6 x 5 mL).
The kit must contain internal standard solution (1 x 300 uL).
The kit must contain dilution solution (1 x 10 mL).
The kit must contain multiparametric calibrator in blood (6 x 3 x 1 mL).
The kit must contain 100 glass vials.
The kit must contain 100 caps for glass vials.
Specifications for the kit's compatibility with the analytical method
The kit must be compatible with a detection method LC-MS/MS (high performance liquid chromatography coupled with tandem mass spectrometry), with electrospray ionization (ESI) source.
The kit must allow analysis of the mentioned compounds in a maximum of 12 minutes/sample.
Specifications for sample preparation:
Extraction of compounds from blood must be accomplished using reaction vials (microcentrifuge tubes).
The kit must be usable to prepare blood samples for LC-MS/MS analysis in a maximum of 3 stages:
1. Extraction of abuse drugs and metabolites
2. Centrifugation
3. Dilution
The kit must contain isotopically labeled internal standards of abuse drugs and metabolites.
The kit must contain solvent for sample dilution.
The kit must be sufficiently sensitive for the use of only 100 µL of blood sample.

Maximum estimated quantity Framework agreement - 15 kits

LOT-0051
Drug analysis kit in urine for LCMSMS.
The analytical kit must be specifically designed for the analysis of drugs of abuse using liquid chromatography coupled with mass spectrometry.
The kit must be validated for in vitro diagnostic (IVD) purposes for screening of drugs of abuse as well as for their quantitative confirmation.
The kit must be validated for the quantitative determination of drugs of abuse through enzymatic hydrolysis of the urine sample.
The kit must be able to be used for the determination of the following drugs of abuse:
Amphetamines: amphetamine, BDB, butylone, 2C-B, 2C-I, cathinone, MBDB, MDA, MDEA, MDMA, MDPV, mephedrone, methamphetamine, methaqualone, methylone, methylphenidate, PMA, ritalinic acid.
Barbiturates: alobarbital, amobarbital, barbital, butalbital, hexobarbital, pentobarbital, phenobarbital, secbutabital, secobarbital, thiopental.
Benzodiazepines: alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, bromazepam, brotizolam, chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, desmetilflunitrazepam, diazepam, estazolam, flunitrazepam, flurazepam, lorazepam, lormetazepam, medazepam, midazolam, nitrazepam, norclobazam, nordiazepam, α-OH-alprazolam, 3-OH-bromazepam, α-OH-midazolam, α-OH-triazolam, oxazepam, prazepam, temazepam, triazolam.
Boosters: gabapentin, pregabalin, promethazine, quetiapine.
Cannabinoids: THC-COOH.
Cocaine: benzoylecgonine, cocaethylene, cocaine, norcocaine.
Others: ketamine, LSD, mescaline, norketamine, O-H-LSD, PCP.
Drug Zs: zaleplon, zolpidem, zopiclone.
Opioids: acetylcodeine, buprenorphine, codeine, dihydrocodeine, EDDP, fentanyl, hydrocodone, hydromorphone, meconin, meperidine, methadone, 6-monoacetylmorphine, morphine, naloxone, naltrexone, norbuprenorphine, norcodeine, norfentanyl, normeperidine, norpentadol, nortilidine, O-desmethyltramadol, oxycodone, oxymorphone, papaverine, propoxyphene, sufentanil, tapentadol, thebaine, tilidine, tramadol.
The kit must allow for the analysis of 108 drugs of abuse and metabolites and must allow for a minimum of 300 tests.
The kit must contain mobile phase A (2 x 700 mL) and mobile phase B (2 x 700 mL).
The kit must contain wash solution for the injector (500 mL).
The kit must contain precipitation reagent (40 mL).
The kit must contain dilution solution (2 x 30 mL).
The kit must contain internal standard (4 x 1 mL lyophilized) and reconstitution solution (5 mL).
The kit must contain enzymatic reagent (2 x 8 mL lyophilized) and hydrolysis buffer (20 mL).
Specifications for the kit's compatibility with the analysis method
The kit must be compatible with an LC-MS/MS detection method (high-performance liquid chromatography coupled with tandem mass spectrometry), with an electrospray ionization source.
The kit must allow for the analysis of the aforementioned compounds in a maximum of 12 minutes/sample.
Specifications for sample preparation
The extraction of compounds from urine must be performed using reaction vials.
The kit must contain the necessary reaction vials for the extraction of compounds of interest.
The kit must be usable to prepare urine samples for LC-MS/MS analysis in a maximum of 4 steps:
1. Extraction of drugs of abuse through enzymatic hydrolysis
2. Centrifugation
3. Transfer
4. Dilution
The kit must contain isotopically labeled internal standards of drugs of abuse, in lyophilized form, which require reconstitution with a suitable solvent available in the kit.
The kit must contain a solvent buffer for the reconstitution of internal standards.
The kit must allow for direct analysis of the compounds without needing a derivatization step that could complicate the extraction protocol.
The kit must be sensitive enough to require only 50 µL of urine sample.
Estimated maximum quantity Framework Agreement - 5 kits